Novelist Larry Donner (Billy Crystal) struggles with writer's block due to his resentment towards his ex-wife Margaret (Kate Mulgrew), who stole his book and garnered mainstream success and critical acclaim with it. Owen Lift (Danny DeVito) is a timid, middle-aged man who still lives with his overbearing, abusive mother (Anne Ramsey). Owen fantasizes of killing his mother but can't summon the courage to bring his desires into fruition. As a student in Larry's community college writing class, Owen is given advice by Larry to view an Alfred Hitchcock film to gain some insight into plot development. He sees Strangers on a Train, in which two strangers conspire to commit a murder for each other, figuring their lack of connection to the victim will, in theory, establish a perfect alibi. Having overheard Larry's public rant that he wish his ex-wife dead, Owen forms a plan to kill Margaret, believing that Larry will respond by killing his mother.
He tracks Margaret down to Hawaii and follows her onto a cruise ship, apparently pushing her overboard while she tries to retrieve an earring that fell out. Owen returns from Hawaii to tell Larry of Margaret's death and that Larry now "owes" him the murder of his mother, lest he inform the police Larry was the killer. After having spent the night drinking alone during the hours of Margaret's disappearance, Larry panics because he lacks a sufficient alibi. That, along with a news report announcing the police suspect foul play, convinces Larry he's the prime suspect. He decides to stay with Owen and his mother in an attempt to hide from the police. Larry meets Mrs. Lift, but despite her harsh treatment of him he refuses to kill her. Eventually, when Mrs. Lift drives Owen to the breaking point, Larry finally relents and agrees to go through with the murder.
After two unsuccessful attempts, Larry flees the Lift home when Mrs. Lift recognizes him as a suspect from a news broadcast about his ex-wife's disappearance. He boards a train to Mexico and, surprisingly, Owen and Mrs. Lift come along so as to avoid having to lie for him. During the journey, Larry's patience with Mrs. Lift reaches its pinnacle when she impolitely gives him advice on writing. He follows her to the caboose with the intent of throwing her from the train, but stops short when she almost falls off on her own. Owen begins having second thoughts about having his mother killed and comes to help Larry rescue her. Mrs. Lift is grateful at her son for saving her, but unappreciative of Larry's help and kicks him, resulting in him losing his balance, landing on the tracks, and breaking his leg.
During his recovery in the hospital, Larry discovers Margaret is still alive; she simply fell overboard by accident and was rescued by a Polynesian fisherman whom she has decided to marry. Much to his annoyance, Larry learns Margaret plans to sell the rights of her ordeal for $1.5 million dollars. On the advice of a fellow patient, Larry chooses to free himself of his obsession with his ex-wife and instead focus on his own life, thereby freeing him of his writer's block.
A year later, Larry has finished a novel based on his experiences with Owen and Mrs. Lift entitled Throw Momma from the Train. Owen visits and informs him that his mother has died (of natural causes) and that he's going to New York City for the release of his own book. Unfortunately, Owen reveals his book is also about their experiences together. Thinking his book has been scooped, an enraged Larry proceeds to strangle him, but stops when Owen shows him the book is a children's pop-up book called, Momma, Owen, and Owen's Friend Larry with the story drastically altered to be suitable for children. Months later, Larry, Owen, and Larry's girlfriend Beth (Kim Greist) vacation together in Hawaii, reflecting on the final chapter of Larry's book. Larry and Owen's books have now become best-sellers, making them both successful writers as well as close friends.
主演:陈佩斯,陈强,傅艺伟
主演:马龙·韦恩斯,莫莉·香侬,格林·特鲁曼,布莱莎·韦伯,黛比·摩根,迈克尔·伊恩·布莱克,罗伯特·普拉尔戈,朱万达斯·坎迪斯,帕蒂·舍尔哈斯,Damon,Vance,Scott,Hunter,Ruben,Vidal,LeBron,Daniel,Jason,Graham,Casey,Hendershot,Spiral,Jackson
主演:梅尔·吉布森,朱迪·福斯特,詹妮弗·劳伦斯,安东·叶利钦,切莉·琼斯,米歇尔·洪,米歇尔·洪,Paul Hodge,Jeff Corbett
主演:亚当·桑德勒,杰姬·桑德勒,伊迪娜·门泽尔
主演:汤姆·汉克斯,艾尔玛·霍尔,马龙·韦恩斯,J·K·西蒙斯,马泰,瑞恩·赫斯特,黛安娜·德拉诺,乔治·华莱士,约翰·麦康奈尔,贾森·韦弗,斯蒂芬·鲁特,Lyne,Odums,沃尔特·K·乔丹,George,Anthony,Bell,格雷戈·格伦伯格
主演:亚历克·吉尼斯,西塞尔·帕克,赫伯特·罗姆,彼得·塞勒斯,凯蒂·约翰逊
主演:彭禺厶,李彧
主演:雷佳音,马丽,赵丽颖,高叶,刘耀文,王骁,陈明昊,潘斌龙,张译,范伟,于和伟,许亚军,李乃文,蒋奇明,阿如那,杨皓宇,许静雅,乔杉,蒋诗萌,王沛禄,丁勇岱,刘奕铁,陈宣菲,史彭元,李晓川,杨一威,许文赫,宋木子,多习,飞凡,蒋鹏宇,王乃训,陈永胜,张壹男,黄炎,宋家腾,林博洋,张磊,李鲲
主演:里奥·蒂普顿,查尔斯·哈尔福德,丹妮尔·霍特默,韦斯顿·拉祖利,Austin Archer,Charlie Stover,Abigail Sakari,Lorelei Olivia Mote,Lonzo Liggins,Sohrab Mirmont,Phoebe Ferro,Rachel Browne,Skyler Peters,Chuck Marra,Andrea Browne,Colleen Baum,Kent Richards
主演:李文植,裴素恩,방준호,김나미
主演:玛拉·威尔逊,丹尼·德维托 Danny DeVito,雷亚·普尔曼
主演:格伦·豪尔顿,凯特琳·奥尔森,罗布·麦克尔亨尼,查理·戴,Danny DeVito
主演:Rob McElhenney,Glenn Howerton,Charlie Day,Kaitlin Olson,Danny DeVito
主演:Billy Crystal,Danny DeVito,Kim Greist
主演:杰克·尼科尔森,雪儿,苏珊·萨兰登,米歇尔·菲佛,理查德·詹金斯
主演:科里·费尔德曼,科里·海姆,黛安·韦斯特,杰森·帕特里克,基弗·萨瑟兰
主演:迈克尔·J·福克斯,海伦·斯雷特,理查德·乔丹
主演:吴耀汉,董骠,郑裕玲,沈殿霞,黄韵诗,何美婷,黎明
主演:梅尔·布鲁克斯,约翰·坎迪,里克·莫拉尼斯,比尔·普尔曼,达芙妮·祖尼加,迪克·范·帕滕,乔治·维内尔,迈克尔·温斯洛,琼·里弗斯,Lorene Yarnell Jansson,约翰·赫特,萨尔·维斯库索,Ronny Graham,Jim J. Bullock,Leslie Bevis,Jim Jackman,迈克·普涅夫斯基,斯蒂芬·托布罗斯基,戴·扬,Rhonda Shear,杰克·雷利,Tom Dreesen,鲁迪·德卢卡,Tony Griffin,里克·杜科蒙,Ken Olfson,Bryan O
主演:梅艳芳,曾志伟,吴君如
主演:斯蒂夫·古根伯格,布巴·史密斯,迈克尔·温斯洛,大卫格拉夫,蒂姆·卡祖林斯基,莎朗·斯通,莱斯利·伊斯特布鲁克,马里昂·拉姆塞,兰斯·金赛,G.W.拜利,博卡·格德斯维特,乔治·盖恩斯,德里克·麦克加特,斯科特·汤姆森,比莉·伯德,乔治·R·罗伯逊,Brian Tochi,布赖恩·巴克尔,大卫·斯佩德,Tab Thacker,科琳·波赫雷
主演:陈友,梅艳芳,钟镇涛,夏文汐,郑丹瑞,郑文雅,吴君如,周宝珊,郑孟霞,苏杏璇,秦煌,苗侨伟
主演:冢本晋也,仙波成明,田口智朗,叶岡伸,藤原京,佐賀充,奈佐健臣
主演:布鲁斯·坎贝尔,Sarah Berry,丹·希克斯,凯茜·韦斯利·德帕瓦
主演:吴耀汉,钟镇涛,午马,黄韵诗,孟海,太保,李志杰,田俊,叶荣祖,田青,西瓜刨
主演:吴耀汉,董骠,郑裕玲,沈殿霞,黄韵诗,何美婷,黎明
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